Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty
نویسندگان
چکیده
منابع مشابه
Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty.
Hypotheses about the functions of ancient proteins and the effects of historical mutations on them are often tested using ancestral protein reconstruction (APR)-phylogenetic inference of ancestral sequences followed by synthesis and experimental characterization. Usually, some sequence sites are ambiguously reconstructed, with two or more statistically plausible states. The extent to which the ...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 2016
ISSN: 0737-4038,1537-1719
DOI: 10.1093/molbev/msw223